Role of Ipratropium Bromide and Tiotropium in Chronic Obstructive Pulmonary Disease
نویسندگان
چکیده
منابع مشابه
Tiotropium Bromide in Chronic Obstructive Pulmonary Disease and Bronchial Asthma
Inhaled bronchodilators are the mainstay of pharmacological treatment for stable chronic obstructive pulmonary disease (COPD), including β2-agonists and muscarinic antagonists. Tiotropium bromide, a long-acting antimuscarinic bronchodilator (LAMA), is a treatment choice for moderate-to-severe COPD; its efficacy and safety have been demonstrated in recent trials. Studies also point to a benefici...
متن کاملCHRONIC OBSTRUCTIVE PULMONARY DISEASE Effect of tiotropium bromide on circadian variation in airflow limitation in chronic obstructive pulmonary disease
Background: In chronic obstructive pulmonary disease (COPD), the degree of circadian variation in forced expiratory volume in 1 second (FEV1) and the influence of anticholinergic blockade is not known. Tiotropium is a long acting inhaled anticholinergic bronchodilator that increases daytime FEV1 in COPD. We hypothesised that tiotropium would modify the overnight change in FEV1, and this would b...
متن کاملA randomised controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease
Background—A study was undertaken to evaluate and compare the eYcacy and safety of tiotropium and ipratropium during long term treatment in patients with stable chronic obstructive pulmonary disease (COPD). Methods—288 patients of mean (SD) age 65 (8) years and forced expiratory volume in one second (FEV1) 41 (12)% predicted participated in a 14 centre, double blind, double dummy, parallel grou...
متن کاملOne-year cost-effectiveness of tiotropium versus ipratropium to treat chronic obstructive pulmonary disease.
The aim of this paper is to assess the health economic consequences of substituting ipratropium with the new, once-daily bronchodilator tiotropium in patients with a diagnosis of chronic obstructive pulmonary disease (COPD). This prospective cost-effectiveness analysis was performed alongside two 1-yr randomised, double-blind clinical trials in the Netherlands and Belgium. Patients had a diagno...
متن کامل[Efficacy of tiotropium bromide (Spiriva) in patients with chronic-obstructive pulmonary disease (COPD) of different severities].
BACKGROUND Aim of this study was to evaluate the efficacy of inhaled Tiotropium bromide in COPD patients of different severities in pneumological practices during a three months clinical trial. METHODS A randomized, double blind, placebo controlled study including COPD-patients (FEV1/FVC < 70 %, FEV1 < or = 70 % predicted; age > or = 40 years; > or = 10 pack years) of different severities was...
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ژورنال
عنوان ژورنال: International Journal of Pulmonary & Respiratory Sciences
سال: 2017
ISSN: 2573-2234
DOI: 10.19080/ijoprs.2017.02.555590